Ammonia → HCID 86746324、化合物

HRID 373391

反応式

HRID 373391 の反応式
[C-:1]#[C-:2].[Na+].[Na+].Br[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]/[CH:15]=[CH:16]\[CH2:17][CH2:18][CH2:19][CH3:20].N>>[CH:20]#[C:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]/[CH:9]=[CH:8]\[CH2:7][CH2:6][CH2:1][CH3:2]

参加物

4

反応物 3

HCID 222AmmoniaHCID 10924215HCID 10924215、化合物HCID 178463197HCID 178463197、化合物2 回

生成物 1

HCID 86746324HCID 86746324、化合物

実験手順

The reaction mixture containing sodium acetylide is then admixed with 1-bromo-Z-10-pentadecene in an amount of 0.8 to 1.2 moles per mole of the sodium acetylide and the reaction is effected at a temperature in the range from -20° to +20° C., usually, for 1 to 5 hours. After completion of the reaction, the reaction mixture is freed from ammonia and washed with water or diluted hydrochloric acid followed by isolation of the pro-duct by a conventional procedure including the methods of solvent extraction, distillation, column chromatography and the like to give the desired Z-12-heptadecen-1-yne in a good yield which is usually in the range from 65 to 85% based on the amount of the sodium metal.

後処理

  1. customis effected at a temperature in the range from -20° to +20° C.
  2. customAfter completion of the reaction
  3. washwashed with water or diluted hydrochloric acid
  4. extractionthe methods of solvent extraction, distillation, column chromatography

出典と根拠

ORDレコード
ord-201b92d3b0da4eb2a0cdad169f53d914
出典データセット
uspto-grants-1992_11
特許番号
US05162596

関連ノート

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