Water → 1,4-Bisacetylamino-2-fluorobenzene

HRID 373443ノート

反応式

HRID 373443 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.O.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C(O)(=O)C>[C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:14](=[O:16])[CH3:15])=[CH:3][C:4]=1[F:12])(=[O:11])[CH3:10]

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 255648n-(4-Amino-2-fluorophenyl)acetamide

生成物 1

HCID 148170801,4-Bisacetylamino-2-fluorobenzene

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
15 °C

実験手順

134.5 g (0.8 mol) of the 1-amino-4-acetylamino-3-fluorobenzene prepared above under A. are heated at 85° C. together with 800 ml of water and 34 g of acetic acid. 86.5 g of acetic anhydride are added to this mixture in the course of one hour. The reaction mixture is subsequently stirred at the same temperature for a further hour and cooled to 15° C. The product which has precipitated is then filtered off, washed twice with 150 ml of water each time and dried.

後処理

  1. customThe product which has precipitated
  2. filtrationis then filtered off
  3. washwashed twice with 150 ml of water each time
  4. customdried

出典と根拠

ORDレコード
ord-af46820c16b94459930855801c4df6e6
出典データセット
uspto-grants-1992_11
特許番号
US05163970

反応ノート

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