Water → HCID 15003621、化合物
反応式
[CH3:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[C:4]([Cl:10])[N:3]=1.[CH3:11][O-:12].[Na+].N1C=CC=NC=1.O>CO>[Cl:10][C:4]1[C:5]([Cl:9])=[C:6]([O:12][CH3:11])[N:7]=[C:2]([CH3:1])[N:3]=1参加物
6
実験手順
A solution containing 38 g (0.17 mol) of 2-methyl-4,5,6-trichloropyrimidine in 200 ml of methanol was cooled in an ice bath to 10`-15° C. and sodium methoxide as a 25 percent solution in methanol was added slowly with stirring until the starting pyrimidine could no longer be detected by GLC analysis. Water was then added and the resulting mixture was extracted with methylene chloride. Removal of the solvent and other volatiles from the extract by evaporation under reduced pressure left the title compound as a white powder melting at 77°-78° C.
後処理
- additionwas added slowly
- extractionthe resulting mixture was extracted with methylene chloride
- customRemoval of the solvent and other volatiles from the
- extractionextract by evaporation under reduced pressure
- waitleft the title compound as a white powder melting at 77°-78° C.
出典と根拠
- ORDレコード
- ord-423b25bb2aec422eb09329449dba1a48
- 出典データセット
- uspto-grants-1992_11
- 特許番号
- US05163995
反応ノート
読み込み中…