1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine → (2S,4S)-N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide

HRID 373505

反応式

HRID 373505 の反応式
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])[CH2:6][CH2:5]1.[F:18][C:19]1[CH:20]=[C:21]2[C@:28]3([C:32](=[O:33])[NH:31][C:30](=[O:34])[NH:29]3)[CH2:27][C@@H:26]([C:35](Cl)=[O:36])[O:25][C:22]2=[CH:23][CH:24]=1>>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:7]1[CH2:6][CH2:5][N:4]([CH2:3][CH2:2][NH:1][C:35]([C@@H:26]2[CH2:27][C@@:28]3([C:32](=[O:33])[NH:31][C:30](=[O:34])[NH:29]3)[C:21]3[C:22](=[CH:23][CH:24]=[C:19]([F:18])[CH:20]=3)[O:25]2)=[O:36])[CH2:9][CH2:8]1

参加物

3

反応物 2

HCID 103991861-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazineHCID 57210646(2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride

生成物 1

HCID 57277562(2S,4S)-N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide

実験手順

This compound was prepared by the similar procedure as in the case of Example 8, excepting that 4-(2-aminoethyl)-1-(2-methoxyphenyl)pyperazine and (2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carbonyl chloride (Reference Example 1) were employed.

後処理

  1. customThis compound was prepared by the similar procedure as in the case of Example 8

出典と根拠

ORDレコード
ord-db86b2de7c4f4826988bf977fda33a2a
出典データセット
uspto-grants-1992_11
特許番号
US05164391

関連ノート

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