Dimethylformamide → 2-Aminopyrimidine-4-carboxamide
反応式
Cl[C:2]1[N:7]=[C:6]([C:8]([NH2:10])=[O:9])[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].C[N:18](C)C=O>>[NH2:18][C:2]1[N:7]=[C:6]([C:8]([NH2:10])=[O:9])[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
The amine of formula (V) is thus obtained, and this is reacted with 2-chloropyrimidine-4-carboxamide of formula (VI) in an aprotic solvent, for example dimethylformamide, in the presence of a base, for example potassium carbonate, at a temperature of 20° to 80° C., especially 20° C. to 40° C., to give a 2-aminopyrimidine-4-carboxamide derivative of formula (I). The compound of formula (I) is, if desired, converted into an acid addition salt.
出典と根拠
- ORDレコード
- ord-750e7675d992434190c9565c5c2ec633
- 出典データセット
- uspto-grants-1992_11
- 特許番号
- US05164397
反応ノート
読み込み中…