HCID 13891111、化合物 → (3S,4S)-3-Hydroxy-4-amino-5-cyclohexyl-1-pentene
反応式
[CH:1]1([CH2:7][C@H:8]2[CH:12]([CH:13]=[CH2:14])[O:11]C(=O)[NH:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O1CCOCC1.O>[OH:11][C@H:12]([C@@H:8]([NH2:9])[CH2:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH:13]=[CH2:14]参加物
5
実験手順
To the resultant 5S-diastereomer from Example 4 (2.06 g, 9.84 mmol) in dioxane (180 ml) and water (120 ml) was added barium hydroxide octahydrate (6.24 g, 19.8 mmol). The mixture was refluxed for 18 h, cooled, filtered, concentrated, taken up in water and extracted with ethyl acetate which was dried over Na2SO4 and evaporated to afford 1.64 9 (91%) of the desired product, m.p.: 59°-61° C.
後処理
- temperatureThe mixture was refluxed for 18 h
- temperaturecooled
- filtrationfiltered
- concentrationconcentrated
- extractionextracted with ethyl acetate which
- dry with materialwas dried over Na2SO4
- customevaporated
出典と根拠
- ORDレコード
- ord-d221a7cb9bae4fc09a44956c6d96a3ae
- 出典データセット
- uspto-grants-1992_11
- 特許番号
- US05164388
反応ノート
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