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Lithium Hydroxide → 2-Indancarboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | 2,2-Dicarboethoxy-indane | HCID 11010777 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Indancarboxylic Acid | HCID 575777 | 71% |
反応手順
Dissolve 2,2-dicarboethoxy-indan (5.67 g, 21.7 mmol) in ethanol (150 mL). Add 1N lithium hydroxide (50 mL) and stir overnight at room temperature. Reflux for 1 hour and concentrate the solution in vacuo. Partition between ethyl acetate and 6N hydrochloric acid. Separate the organic phase and wash with brine. Dry (MgSO4) and evaporate the solvent i n vacuo to give an off-white solid. Distill (120°-160° C. @0 .2-0.5 mmHg) to give 2-carboxy-indan (2.5 g, 71%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05420271 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-925e6b2b9f4843428e1f54535f85a285 |
| 出典メモ | uspto-grants-1995_05 |