4-Benzyl-2-(methoxymethyl)morpholine → 2-(Methoxymethyl)morpholine

HRID 373916ノート

反応式

HRID 373916 の反応式
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:16][O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

参加物

4

反応物 1

HCID 103534614-Benzyl-2-(methoxymethyl)morpholine

生成物 1

HCID 149332022-(Methoxymethyl)morpholine収率 86.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒2 回HCID 887Methanol溶媒

反応条件

温度
100 °C

実験手順

N-Benzyl-2-methoxymethylmorpholine (412.3 g) is dissolved in methanol (2 liters), and thereto is added 10% palladium-carbon (33 g), and the mixture is stirred under hydrogen pressure of 9 kg/cm2 at 100° C. After completion of the reaction, palladium-carbon is filtered off, and the solvent is distilled off under atmospheric pressure to give a pale yellow oily substance. The oily substance is distilled under reduced pressure to give the title compound (212.3 g) as colorless liquid.

後処理

  1. filtrationis filtered off
  2. distillationthe solvent is distilled off under atmospheric pressure
  3. customto give a pale yellow oily substance
  4. distillationThe oily substance is distilled under reduced pressure

出典と根拠

ORDレコード
ord-f606f3d2ef294a8882714e8beb3bcae4
出典データセット
uspto-grants-1992_11
特許番号
US05166203

反応ノート

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