Acetic Acid → 4-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

HRID 373950

反応式

HRID 373950 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:30]=[CH:29][C:17]([CH:18]=[CH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=[O:13].C(O)(=[O:33])C.OO>ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:15]=[CH:16][C:17]([CH:18]=[CH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:27][CH:28]=2)=[CH:29][CH:30]=1)(=[O:33])=[O:13]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 545127564-(4-(2-Quinolinylmethylsulfinyl)styryl)benzoic acid

生成物 1

HCID 544571334-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 3 mmol of the sulfinyl compound from Step A in acetic acid (40 mmol) is added 30% hydrogen peroxide (2 ml). The mixture is stirred at ambient temperature and assayed by TLC. Upon disappearance of the sulfinyl starting compound, the reaction mixture is diluted with dichloromethane, washed with dilute aqueous sodium bisulfite and water, dried and evaporated to give 4-(4-(2-quinolinylmethylsulfonyl)styryl)benzoic acid.

後処理

  1. washwashed with dilute aqueous sodium bisulfite and water
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-01cf7ebcee884278be3216537458d942
出典データセット
uspto-grants-1992_11
特許番号
US05166210

関連ノート

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