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Hydrochloric Acid → HCID 178441732、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenolphthalein | HCID 4764 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-butyl-2-methyl-5-[(2'-(N-triphenylmethyl-tetrazol-5-yl)biphen-4-yl)methyl]pyrimidin-4(3H)-one | HCID 135518798 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178441732 | HCID 178441732 | — |
反応手順
The title compound may be prepared by dissolving 6-butyl-2-methyl-5-[(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl]pyrimidin-4(3H)-one in methanol and adding excess concentrated HCl and stirring for 10-30 minutes. An indicator quantity of phenolphthalein is added followed by 10% NaOH solution until pink. Excess acetic acid is added and the mixture is extracted three times with ether. The combined organic material is dried over MgSO4, stripped of solvent in vacuo, and MPLC'd to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05166206 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-3ee7bfc4eb934a9e92e80e920b709c48 |
| 出典メモ | uspto-grants-1992_11 |