N-Acetyl-L-Cysteine → 2-Acetamido-3-[[2-[(4-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]propanoic acid

HRID 3740

反応式

HRID 3740 の反応式
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1.[C:21]([NH:24][C@H:25]([C:28]([OH:30])=[O:29])[CH2:26][SH:27])(=[O:23])[CH3:22]>>[C:21]([NH:24][CH:25]([CH2:26][S:27][S:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:2](=[O:1])[NH:3][C:11]1[CH:16]=[CH:15][C:14]([S:17](=[O:19])(=[O:18])[NH2:20])=[CH:13][CH:12]=1)[C:28]([OH:30])=[O:29])(=[O:23])[CH3:22]

参加物

3

反応物 2

HCID 12035N-Acetyl-L-CysteineHCID 4629384-(3-Oxo-1,2-benzothiazol-2-yl)benzenesulfonamide

生成物 1

HCID 64835582-Acetamido-3-[[2-[(4-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]propanoic acid収率 81.6%

実験手順

This compound was prepared according to the method of Example 132 using 0.8 g (2.4 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzenesulfonamide and 0.39 g (2.4 mmol) of N-acetyl-L-cysteine. The product was washed with ether and dried in vacuo to give 0.92 g of the title compound, mp 218°-220° C.

後処理

  1. customThis compound was prepared
  2. washThe product was washed with ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-85957d48a087410d9c293b7d5c14f82e
出典データセット
uspto-grants-1998_03
特許番号
US05734081

関連ノート

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