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HRID 374112作成日：2026年10月26日
Tris(hydroxymethyl)nitromethane → 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine
https://huagongshe.com/reaction/374112
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tris(hydroxymethyl)nitromethane | HCID 31337 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | N~1~-Benzyl-N~2~-methylethane-1,2-diamine | HCID 10920861 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine | HCID 14938638 | — |
反応手順
To a mixture of tris(hydroxymethyl)nitromethane (118.9 g), sodium bicarbonate (40 g) and water (1000 ml), N-benzyl-N'-methylethylenediamine (123 g) is added, and the reaction mixture is heated at about 50° C. for 2 hours. After cooling, the solution is extracted with dichloromethane, and the organic layer is washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The solvent is evaporated under reduced pressure to give 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05166341 |
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| 出典データセット | uspto-grants-1992_11 |
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| ORD ID | ord-a9b2f3e1505e4ee9b870b600161f91c4 |
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| 出典メモ | uspto-grants-1992_11 |
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