関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylhydantoin | HCID 6491 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | Nilutamide | HCID 4493 | — |
反応手順
30 ml of dimethylsulfoxide and 24.8 grams of 2-nitro-5-chloro trifluoromethylbenzene were introduced at 20° C. with stirring into 100 ml of dimethylsulfoxide, 12.80 grams of 5,5-dimethyl-hydantoin and 6.28 grams of potassium hydroxide in the form of flakes. The mixture was heated to 110° C. for a period of time variable between 3 and 18 hours. The product was characterized and determined by thin layer chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05166358 |
|---|
| 出典データセット | uspto-grants-1992_11 |
|---|
| ORD ID | ord-2ae4db263d7146fbaf6b90c5a74f8452 |
|---|
| 出典メモ | uspto-grants-1992_11 |
|---|
