関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylhydantoin | HCID 6491 | — |
| 反応物 | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| 触媒 | Copper | HCID 23978 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Nilutamide | HCID 4493 | — |
反応手順
71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05166358 |
|---|
| 出典データセット | uspto-grants-1992_11 |
|---|
| ORD ID | ord-f33c2a567db743aeaaf8f1ed8c025a89 |
|---|
| 出典メモ | uspto-grants-1992_11 |
|---|
