Neopentylamine → N-cyano N'-(2,2-dimethylpropyl)-2-pyridinecarboximidamide

HRID 374132ノート

反応式

HRID 374132 の反応式
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][C:14]([CH3:18])([CH3:17])[CH2:15][NH2:16]>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:16][CH2:15][C:14]([CH3:18])([CH3:17])[CH3:13])#[N:2]

参加物

4

反応物 2

HCID 79882NeopentylamineHCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

生成物 1

HCID 19734543N-cyano N'-(2,2-dimethylpropyl)-2-pyridinecarboximidamide収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 2,2-dimethylpropylamine (0.30 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from dichloromethane-diethyl ether to give the title compound (0.63 g, 2.9 mmol, yield: 94%) as colorless needles.

後処理

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from dichloromethane-diethyl ether

出典と根拠

ORDレコード
ord-b23c20c0a12a4d68b8fa69d5b39b103a
出典データセット
uspto-grants-1992_11
特許番号
US05166347

反応ノート

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