Phenethylamine → N-cyano-N'-(2-phenylethyl)-3-furancarboximidamide

HRID 374192ノート

反応式

HRID 374192 の反応式
[C:1]([N:3]=[C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)OC)#[N:2].[C:12]1([CH2:18][CH2:19][NH2:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[C:1]([NH:3][C:4]([C:7]1[CH:11]=[CH:10][O:9][CH:8]=1)=[N:20][CH2:19][CH2:18][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)#[N:2]

参加物

4

反応物 2

HCID 1001PhenethylamineHCID 19734520Methyl N-cyano-3-furancarboximidate

生成物 1

HCID 19754249N-cyano-N'-(2-phenylethyl)-3-furancarboximidamide収率 79.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methyl N-cyano-3-furancarboximidate (0.30 g, 2.0 mmol) was dissolved in methanol (10 ml), and 2-phenylethylamine (0.27 g, 2.2 mmol) was added. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from diethyl ether to give the title compound (0.38 g, 1.59 mmol, yield: 79%) as colorless crystals.

後処理

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from diethyl ether

出典と根拠

ORDレコード
ord-147fd364e36749d098461403363edd79
出典データセット
uspto-grants-1992_11
特許番号
US05166347

反応ノート

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