Acetic Acid → Methyl 2-thiophenecarboximidate

HRID 374193ノート

反応式

HRID 374193 の反応式
[C:1]([C:3]1[S:4][CH:5]=[CH:6][CH:7]=1)#[N:2].C[O-].[Na+].[C:11](O)(=[O:13])C>CO>[S:4]1[CH:5]=[CH:6][CH:7]=[C:3]1[C:1](=[NH:2])[O:13][CH3:11]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 660872-ThiophenecarbonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 398427Methyl 2-thiophenecarboximidate収率 817.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-cyanothiophene (5.46 g, 50 mmol) was dissolved in methanol (25 ml), and sodium methoxide (0.27 g, 5 mmol) was added. The mixture was stirred at room temperature for 18 hours. After the reaction was completed, acetic acid (0.33 g, 5.5 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (40 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-thiophenecarboximidate (6.35 g) as a yellow oil.

後処理

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (40 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8cf7d2e265df4e02b61ed7c7f849188d
出典データセット
uspto-grants-1992_11
特許番号
US05166347

反応ノート

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