Acetic Acid → Methyl 3-thiophenecarboximidate

HRID 374196ノート

反応式

HRID 374196 の反応式
[C:1]([C:3]1[CH:7]=[CH:6][S:5][CH:4]=1)#[N:2].C[O-].[Na+].[C:11](O)(=[O:13])C>CO>[S:5]1[CH:6]=[CH:7][C:3]([C:1](=[NH:2])[O:13][CH3:11])=[CH:4]1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 74231Thiophene-3-carbonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 15211507Methyl 3-thiophenecarboximidate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-cyanothiophene (0.66 g, 6.0 mmol) was dissolved in methanol (6 ml), and sodium methoxide (0.03 g, 0.6 mmol) was added. The mixture was stirred at room temperature for 28 hours. After the reaction was completed, acetic acid (0.03 g, 0.6 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (50 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 3-thiophenecarboximidate.

後処理

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (50 ml) was added to the concentrated residue, and insolubles
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8177c25273e0484e94c1fa59ec065a60
出典データセット
uspto-grants-1992_11
特許番号
US05166347

反応ノート

読み込み中…