化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl ethylphosphonate → Ethyl 3-(ethoxycarbonyl)-3-(ethoxy-ethylphosphinyl)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl ethylphosphonate | HCID 6534 | — |
| 反応物 | Diethyl fumarate | HCID 638144 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 3-(ethoxycarbonyl)-3-(ethoxy-ethylphosphinyl)propionate | HCID 15052087 | 90.9% |
反応手順
172 g of diethyl fumarate are slowly added at 65°-70° C. under nitrogen to a mixture of 140 g of diethyl ethanephosphonate in 46 g of ethanol. After a further 3 hours the solvent (excess ethanol and diethyl ether) is removed by vacuum distillation; the crude product is obtained in a yield of 285 g with a 95.7% purity, which corresponds to a theoretical yield of 90.9%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05166385 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-d0758f6a49c84695af6163c5c5e758e4 |
| 出典メモ | uspto-grants-1992_11 |