化工社化工社 化学情報印刷レポート · 研究参考用
Phenol → Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Methyl 2-chloroacrylate | HCID 6659 | — |
| 反応物 | Phosphonic acid, phenyl-, dimethyl ester | HCID 75234 | — |
| 生成物 | Methyl 3-(phenyl-methoxyphosphinyl)-2-chloropropionate | HCID 15052091 | 90.1% |
反応手順
138 g of dimethyl phenylphosphonate are slowly added at 20° C. under nitrogen to a solution of 120.5 g of methyl 2-chloroacrylate and 94 g of phenol. After a reaction time of 3 hours at 70° C. phenetole is removed by vacuum distillation. The residue represents 267 g of crude product with a 93.0% purity, which corresponds to a theoretical yield of 90.1%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05166385 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-3307f53977b44fc8a76ecf241fbf580d |
| 出典メモ | uspto-grants-1992_11 |