Glycine, N-acetyl-N-phenyl- → (1R, 2R, 3S)-2,3-bis(hydroxymethyl)-1-cyclobutylamine N-acetyl-L-phenylglycine

HRID 374265

反応式

HRID 374265 の反応式
[OH:1][CH2:2][CH:3]1[CH:6]([CH2:7][OH:8])[CH2:5][CH:4]1[NH2:9].[CH3:10][C:11]([N:13]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:14][C:15]([OH:17])=[O:16])=[O:12]>CO>[OH:1][CH2:2][C@@H:3]1[C@@H:6]([CH2:7][OH:8])[CH2:5][C@H:4]1[NH2:9].[CH3:10][C:11]([N:13]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:14][C:15]([OH:17])=[O:16])=[O:12]

参加物

4

反応物 2

HCID 68483Glycine, N-acetyl-N-phenyl-HCID 197942472,3-Bis(hydroxymethyl)-1-cyclobutylamine

生成物 1

HCID 131717654(1R, 2R, 3S)-2,3-bis(hydroxymethyl)-1-cyclobutylamine N-acetyl-L-phenylglycine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

913 mg of (1RS, 2RS, 3SR)-2,3-bis(hydroxymethyl)-1-cyclobutylamine was dissolved in 30 ml of methanol. Then 1340 mg of N-acetyl-L-phenylglycine was added thereto to form salt. The reaction mixture was concentrated under reduced pressure. 15 ml of isopropyl alcohol was added to the residue followed by fractional recrystallization. Thus 403.8 mg of (1R, 2R, 3S)-2,3-bis(hydroxymethyl)-1-cyclobutylamine/N-acetyl-L-phenylglycine salt was obtained.

後処理

  1. customto form salt
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. addition15 ml of isopropyl alcohol was added to the residue
  4. customfollowed by fractional recrystallization

出典と根拠

ORDレコード
ord-f8c228103fd845eda2655b4240e94594
出典データセット
uspto-grants-1992_11
特許番号
US05166397

関連ノート

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