Carbon Dioxide → 2,6-Dichloro-3,5-difluorophenol
反応式
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11])C(O)=O.CN(C)C=O.C(=O)=O.C1(C)C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([F:14])=[CH:4][C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11]参加物
6
実験手順
50 g of 3,5-dichloro-2,6-difluoro-4-hydroxybenzoic acid and 10 ml of dimethylformamide are mixed, and the mixture is heated. Carbon dioxide is evolved at 105°-130° C., and the mixture is allowed to react at this temperature until the reaction is complete. After this, 200 ml of toluene and then 80 ml of water are stirred in, the phases are separated, and the organic phase is dried and then distilled. This gives 34 g of the product having a boiling point of 87°-88° C. and a refractive index of [n]D20 : 1.5310.
後処理
- temperaturethe mixture is heated
- customis evolved at 105°-130° C.
- customto react at this temperature until the reaction
- customare separated
- customthe organic phase is dried
- distillationdistilled
出典と根拠
- ORDレコード
- ord-d60ebe012c544bc693d0978ccf5ab60d
- 出典データセット
- uspto-grants-1992_11
- 特許番号
- US05166392
反応ノート
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