1-Chloro-2-fluoroethane → 2-(2-Fluoroethylthio)-phenylsulfonamide

HRID 374349

反応式

HRID 374349 の反応式
C(N(CC)CC)C.[SH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16].Cl[CH2:20][CH2:21][F:22]>CO>[F:22][CH2:21][CH2:20][S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16]

参加物

4

反応物 2

HCID 129831-Chloro-2-fluoroethaneHCID 198097532-Mercaptophenylsulfonamide triethylamine salt

生成物 1

HCID 198097542-(2-Fluoroethylthio)-phenylsulfonamide収率 74.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 5.8 g of the 2-mercaptophenylsulfonamide triethylamine salt obtained in accordance with Example H6 and 1.7 g of 2-chloro-1-fluoroethane in 40 ml of methanol is stirred in a bomb tube for 23 hours at a temperature of +50° to +55° C. The reaction mixture is then evaporated and water is added to the residue which remains. The mixture is extracted with ethyl acetate, and the organic phase is washed and dried. Evaporation of the solution gives 3.5 g of 2-(2-fluoroethylthio)-phenylsulfonamide (74.5% of theory) having a melting point of +83° to +85° C.

後処理

  1. customThe reaction mixture is then evaporated
  2. additionwater is added to the residue which
  3. extractionThe mixture is extracted with ethyl acetate
  4. washthe organic phase is washed
  5. customdried
  6. customEvaporation of the solution

出典と根拠

ORDレコード
ord-ed4db594ab6449c09e87eb753c4cf549
出典データセット
uspto-grants-1992_11
特許番号
US05166430

関連ノート

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