関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 反応物 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Fluoxetine | HCID 3386 | — |
反応手順
A mixture of 4.0 g (0.0357 mol) potassium t-butoxide, 30 ml of N-methylpyrrolidone, 5.0 g (0.0303 mol) of 1-phenyl-3-N-methylaminopropan-1-ol and 7.4 g (0.0410 mol) of 1-chloro-4-trifluoromethylbenzene was heated to 140° C. and the reaction mixture was agitated at this temperature for 3 hours. The mixture was then cooled to 20°-25° C. and 40 ml of toluene and 60 ml of water were added. The layers were separated and water-phase was extracted with 40 ml of toluene. The combined toluene-phases were washed four times with 20 ml of water. Toluene was evaporated under reduced pressure yielding 7.19 g of the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05166437 |
|---|
| 出典データセット | uspto-grants-1992_11 |
|---|
| ORD ID | ord-b34bae52177e4aeaa7f77a82ff9cb36a |
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| 出典メモ | uspto-grants-1992_11 |
|---|
