N-Acetyl-L-Cysteine → HCID 178418393、化合物

HRID 3745

反応式

HRID 3745 の反応式
[CH3:1][CH:2]([CH2:17][CH3:18])[CH:3]([N:7]1[C:11](=[O:12])[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[S:8]1)[C:4]([OH:6])=[O:5].C(N[C@H:23]([C:26]([OH:28])=[O:27])[CH2:24][SH:25])(=O)C>CO>[C:11]([NH:7][SH:25]([CH2:24][CH2:23][C:26]([OH:28])=[O:27])[S:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[C:11]([NH:7][CH:3]([CH:2]([CH3:1])[CH2:17][CH3:18])[C:4]([OH:6])=[O:5])=[O:12])(=[O:12])[CH3:10]

参加物

4

反応物 2

HCID 12035N-Acetyl-L-CysteineHCID 178926623-Methyl-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)pentanoic acid

生成物 1

HCID 178418393HCID 178418393、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 0.58 g (2.2 mmol) of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]isothiazol-2-yl)pentanoic acid in 20 mL of methanol was treated with 0.36 g (2.2 mmol) of N-acetyl-L-cysteine and the reaction was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was triturated with 100 mL of 60° C. water. The water was decanted and the solid was dissolved in 50 mL of ethyl acetate. The organic solution was dried (MgSO4), filtered and evaporated in vacuo to give the title compound as a white, solid foam, mp 85°-90° C.

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was triturated with 100 mL of 60° C. water
  3. customThe water was decanted
  4. dissolutionthe solid was dissolved in 50 mL of ethyl acetate
  5. dry with materialThe organic solution was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-8b264e10282d462783a148a83796833e
出典データセット
uspto-grants-1998_03
特許番号
US05734081

関連ノート

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