Acetone → Benzo[1,3]dioxole-2,2-dicarboxylic acid diethyl ester

関与物質

反応手順

A mixture of 0.240 g of the above oxazolidinone, 0.250 g of diethylbromomalonate, 0.500 g of anhydrous potassium carbonate and 10 ml of acetone is stirred overnight, filtered, washed with acetone and evaporated to a brown oil. The oil is purified by flash chromatography, eluting with 5% acetone/toluene. The pure fractions are combined and evaporated giving (S,R)5-(1-naphthyloxymethyl)-2-oxo-3-oxazolidinyl)propyl)1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester as a colorless oil.

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