Methylamine → 6-(Methylamino)pyridine-3-carbonitrile

HRID 374575ノート

反応式

HRID 374575 の反応式
C[N:2]([CH:4]=[C:5]([C:10]#[N:11])[CH:6]=[CH:7][C:8]#[N:9])C.[CH3:12]N>CN(C=O)C>[CH3:12][NH:9][C:8]1[CH:7]=[CH:6][C:5]([C:10]#[N:11])=[CH:4][N:2]=1

参加物

4

反応物 2

HCID 6329MethylamineHCID 37308924-[(Dimethylamino)methylidene]pent-2-enedinitrile

生成物 1

HCID 178608996-(Methylamino)pyridine-3-carbonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

7.4 g of dimethylaminomethylene-glutacononitrile, 100 ml of DMF and 4.4 g of 35.6% strength aqueous methylamine solution were held for 2 hours at 80° C. in an 0.3 l V4A autoclave. After the mixture had been removed and concentrated, 6.4 g of 2-methylamino-5-cyanopyridine (purity 93%) were obtained, which corresponds to 90.2% of theory.

後処理

  1. customAfter the mixture had been removed
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-c0ad1f8d48b14744ae5ce323da9b4292
出典データセット
uspto-grants-1996_01
特許番号
US05480995

反応ノート

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