関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Ammonium Persulfate | HCID 62648 | — |
| 反応物 | (2-Chloro-4,5-difluorophenyl)(phenyl)methanone | HCID 704945 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Chloro-4,5-difluorobenzoic acid | HCID 737171 | 80.8% |
反応手順
8 g of ammonium peroxodisulfate are introduced into 5 g (19.8 mmol ) of 2-chloro-4,5-difluorobenzophenone and 20 g of glacial acetic acid and the mixture is heated at 90° C. (12 h). 100 g of 70% sulfuric acid are then added and the mixture is heated for 2 h at 150° C. Dilution with 200 g of water and filtration gives 3.1 g (16.0 mmol, 81%) of 2-chloro-4,5-difluorobenzoic acid (purity (GC) ca. 92%). Recrystallization from water gives 2.5 g of product melting at 104° C.-105° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05481032 |
|---|
| 出典データセット | uspto-grants-1996_01 |
|---|
| ORD ID | ord-57ce944fb97645a09a59dd154d8b1826 |
|---|
| 出典メモ | uspto-grants-1996_01 |
|---|
