5-Ethoxyoxazole → Dimethyl 5-hydroxypyridine-3,4-dicarboxylate
反応式
[C:1]([O:9][CH3:10])(=[O:8])/[CH:2]=[CH:3]/[C:4]([O:6][CH3:7])=[O:5].C([O:13][C:14]1O[CH:17]=[N:16][CH:15]=1)C>>[CH3:7][O:6][C:4]([C:3]1[CH:17]=[N:16][CH:15]=[C:14]([OH:13])[C:2]=1[C:1]([O:9][CH3:10])=[O:8])=[O:5]参加物
3
実験手順
Dimethyl fumarate (781 mg; 1.1 eq.) was added to 5-ethoxyoxazole (557.3 mg; 4.9 mmol), and the mixture was reacted at 120° C. for 1.5 hours. The reaction residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 2:1), to give crude crystals of the title compound. Yield: 730 mg (70.2%). The crude crystals were recrystallized from dichloromethane-hexane, to give colorless plates.
後処理
- customthe mixture was reacted at 120° C. for 1.5 hours
- customThe reaction residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane 2:1)
出典と根拠
- ORDレコード
- ord-700ec23cf79745269df3f782f824b98b
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420275
反応ノート
読み込み中…