N-[3,5-Bis(trifluoromethyl)benzyl]-2-chloro-N-methyl-4-phenyl-3-quinolinecarboxamide → N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylamino-4-phenyl-3-quinolinecarboxamide

HRID 374994ノート

反応式

HRID 374994 の反応式
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:11](Cl)=[N:12][C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:9].[CH3:37][NH2:38].CO>C(O)C>[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:11]([NH:38][CH3:37])=[N:12][C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:9]

参加物

4

反応物 2

HCID 21463112N-[3,5-Bis(trifluoromethyl)benzyl]-2-chloro-N-methyl-4-phenyl-3-quinolinecarboxamideHCID 57454252Monomethylamine methanol

生成物 1

HCID 21463329N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylamino-4-phenyl-3-quinolinecarboxamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the compound obtained in Example 269 (100 mg) in ethanol (4 ml) was added 40% MeNH2 -methanol (12 ml), and the mixture was stirred for 4 hours with heating under reflux. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried and evaporated to yield the title compound as colorless crystals (65 mg).

後処理

  1. temperaturewith heating
  2. temperatureunder reflux
  3. customThe solvent was evaporated
  4. dissolutionthe residue was dissolved in ethyl acetate
  5. washThe solution was washed with water
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-9e6d94a7008f481ca4e4b21b9fdad631
出典データセット
uspto-grants-1996_01
特許番号
US05482967

反応ノート

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