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Sodium hydride → Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 2-bromooctanoate | HCID 95580 | — |
| 反応物 | HCID 178526856 | HCID 178526856 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate | HCID 10062368 | — |
反応手順
4-Nitroimidazole (0.29 moles, 32.9 g in 30 ml DMF was treated portionwise with sodium hydride (0.29 moles, 11.6 g. 60% in mineral oil) and stirred for 45 minutes. Ethyl 2-bromooctanoate (0.29 moles, 73.1 g) was added dropwise over 1 hour. The reaction was stirred overnight at room temperature, poured onto ice water, and extracted with ethyl acetate. The organic phase was washed with brine, dried and concentrated to yield 91 g of ethyl 2-(4-nitro-1H-imidazol-1-yl)octanoate. (MS)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05484780 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-dbd66e6369174d8aa63f577dbde71f8d |
| 出典メモ | uspto-grants-1996_01 |