化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → 3-Bromo-5-fluoro-2-iodoaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Stannous chloride dihydrate | HCID 61436 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-Bromo-5-fluoro-2-iodo-3-nitrobenzene | HCID 19429770 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-Bromo-5-fluoro-2-iodoaniline | HCID 19429794 | 76% |
反応手順
Treat 1-iodo-2-nitro-4-fluoro-6-bromobenzene (5.0 g, 14.46 mmol) with tin (II) chloride dihydrate (12 g, 58 mmol) in refluxing ethanol (150 mL). Stir at reflux for 24 hours, pour into a mixture of ethyl acetate (200 mL) and saturated sodium hydrogen carbonate (500 mL). Filter and wash the filtrate with saturated sodium hydrogen carbonate (200 mL) and water (200 mL). Dry (MgSO4), evaporate the solvent in vacuo and purify by silica gel chromatography to give the title compound as an off-white solid (3.45 g, 76%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05484814 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-c30450a0f19a4e75a7a579bb0a4419a3 |
| 出典メモ | uspto-grants-1996_01 |