Ethyl 2-aminooxypropanoate → (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-ethoxy-1-oxopropan-2-yl)oxyiminoacetic acid

HRID 375273ノート

反応式

HRID 375273 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=O)[C:8]([OH:10])=[O:9])[N:6]=1.[CH2:12]([O:14][C:15]([CH:17]([O:19][NH2:20])[CH3:18])=[O:16])[CH3:13]>CN(C)C=O.CO>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:20]/[O:19][CH:17]([C:15]([O:14][CH2:12][CH3:13])=[O:16])[CH3:18])/[C:8]([OH:10])=[O:9])[N:6]=1

参加物

5

反応物 2

HCID 548209Ethyl 2-aminooxypropanoateHCID 127833204-Thiazoleacetic acid, 2-amino-alpha-oxo-

生成物 1

HCID 13729186(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(1-ethoxy-1-oxopropan-2-yl)oxyiminoacetic acid収率 86.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

17.2 g of (2-amino-4-thiazolyl)glyoxylic acid are added whilst cooling with ice to a solution of 14.6 g of O-(1-ethoxycarbonylethyl)hydroxylamine in 20 ml of dimethylformamide. The solution is stirred for 12 hours without cooling, and then diluted with 180 ml of methanol. In order to complete crystallisation, stirring continues for 5 hours at -5°, and then the product is filtered off by suction and dried. 24.7 g (86%) of the title compound are obtained. M.p.: 166°.

後処理

  1. temperaturewithout cooling
  2. customcrystallisation
  3. stirringstirring
  4. waitcontinues for 5 hours at -5°
  5. filtrationthe product is filtered off by suction
  6. customdried

出典と根拠

ORDレコード
ord-3d2a7f428fa34bbe8c29628851aae31b
出典データセット
uspto-grants-1996_01
特許番号
US05484928

反応ノート

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