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3-(2,4-Dimethoxyphenyl)prop-2-enoic acid → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxyphenyl)ethenyl)-1,3-dipropyl-, (E)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(2,4-Dimethoxyphenyl)prop-2-enoic acid | HCID 85636 | — |
| 反応物 | 5,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione | HCID 5098605 | — |
| 生成物 | 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxyphenyl)ethenyl)-1,3-dipropyl-, (E)- | HCID 6448780 | — |
反応手順
Substantially the same procedure as in Reference Example 1 was repeated using 3.0 g (13.3 mmol) of 5,6-diamino-1,3-dipropyluracil and 3.04 g (14.60 mmol) of 2,4-dimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.26 g (yield of Compound 24 as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05484920 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-a523df9c0e4647fd9aacc2183c8062d2 |
| 出典メモ | uspto-grants-1996_01 |