Phenethylamine, m-trifluoromethyl- → HCID 18993025、化合物

HRID 375518

反応式

HRID 375518 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][NH2:11])[CH:6]=[CH:7][CH:8]=1.Cl[C:15]1[C:16]2[CH:23]=[C:22]([CH3:24])[O:21][C:17]=2[N:18]=[CH:19][N:20]=1>>[CH3:24][C:22]1[O:21][C:17]2[N:18]=[CH:19][N:20]=[C:15]([NH:11][CH2:10][CH2:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:12])([F:13])[F:1])[CH:4]=3)[C:16]=2[CH:23]=1

参加物

3

反応物 2

HCID 104223Phenethylamine, m-trifluoromethyl-HCID 189930284-Chloro-6-methylfuro[2,3-d]pyrimidine

生成物 1

HCID 18993025HCID 18993025、化合物

反応条件

温度
230 °C

実験手順

A mixture of 1.9 g of 2-[3-(trifluoromethyl)phenyl]ethylamine and 1.6 g of 4-chloro-6-methylfuro[2,3-d]pyrimidine was heated for ten minutes at 230° C. The mixture was then cooled and the product extracted in ethyl acetate/water. The organic phase was separated, washed with water, dried over magnesium sulfate, filtered, and concentrated. The residue was chromatographed on a silica column using toluene and acetone as eluent. Yield 0.97 g. M.P. 119° C.

後処理

  1. temperatureThe mixture was then cooled
  2. extractionthe product extracted in ethyl acetate/water
  3. customThe organic phase was separated
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. customThe residue was chromatographed on a silica column

出典と根拠

ORDレコード
ord-a8fbc2d566584d2899a004f926768274
出典データセット
uspto-grants-1996_01
特許番号
US05486516

関連ノート

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