4-tert-Butylphenol → 1-(Allyloxy)-4-tert-butylbenzene

HRID 375587ノート

反応式

HRID 375587 の反応式
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].Cl[CH2:13][CH:14]=[CH2:15].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH3:4][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:11][CH2:15][CH:14]=[CH2:13])=[CH:9][CH:10]=1)([CH3:1])[CH3:3]

参加物

5

反応物 3

HCID 73934-tert-ButylphenolHCID 7850Allyl chlorideHCID 11430Potassium Carbonate

生成物 1

HCID 6001241-(Allyloxy)-4-tert-butylbenzene

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 45 g 4-(1,1-dimethylethyl)phenol, 30 g 3-chloro-1-propene, 50 g anhydrous potassium carbonate and 250 ml 2-butanone was refluxed for 15 hours, after which time the solvent was removed in a rotary evaporator. Water was added to dissolve the potassium salts and the product extracted twice with ether. The ether layer was dried, removed, and the product distilled. The 50 grams of 1-(1,1-dimethylethyl)-4-(2-propenyloxy)benzene was found to boil at 70°-75° C. at 0.2 mm Hg, listed in Table 1 as compound I-4)

後処理

  1. temperaturewas refluxed for 15 hours
  2. customafter which time the solvent was removed in a rotary evaporator
  3. additionWater was added
  4. dissolutionto dissolve the potassium salts
  5. extractionthe product extracted twice with ether
  6. dry with materialThe ether layer was dried
  7. customremoved
  8. distillationthe product distilled
  9. customto boil at 70°-75° C. at 0.2 mm Hg

出典と根拠

ORDレコード
ord-a451815d4b3a4939b1c7aca8fb4fc062
出典データセット
uspto-grants-1996_01
特許番号
US05486533

反応ノート

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