2,3-Dichloro-1,1,1,4,4,4-hexafluorobut-2-ene → 2-(1-Chloro-2,2,2-trifluoroethyl)-2-trifluoromethyl-[1,3]-dioxolo[4,5-b]pyridine

HRID 37568

反応式

HRID 37568 の反応式
[OH:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[C:10](=[C:15]([Cl:20])[C:16]([F:19])([F:18])[F:17])[C:11]([F:14])([F:13])[F:12]>>[Cl:20][CH:15]([C:10]1([C:11]([F:12])([F:13])[F:14])[O:1][C:2]2=[N:3][CH:4]=[CH:5][CH:6]=[C:7]2[O:8]1)[C:16]([F:19])([F:18])[F:17]

参加物

3

反応物 2

HCID 93372,3-Dichloro-1,1,1,4,4,4-hexafluorobut-2-eneHCID 178516237HCID 178516237、化合物

生成物 1

HCID 189959422-(1-Chloro-2,2,2-trifluoroethyl)-2-trifluoromethyl-[1,3]-dioxolo[4,5-b]pyridine

実験手順

11 g of 2,3-dihydroxypyridine were reacted with 23.5 g of 2,3-dichloro-1,1,1,4,4,4-hexafluorobut-2-ene as described in Example 2. After distillation under high vacuum, the product was obtained in an amount of 15.5 g (=50% of theory) in the form of colourless crystals. The NMR spectra showed the following characteristic absorptions: 19F NMR: -68.5 and -81.6 ppm. 1H NMR: 4.81 ppm.

後処理

  1. distillationAfter distillation under high vacuum
  2. customthe product was obtained in an amount of 15.5 g (=50% of theory) in the form of colourless crystals

出典と根拠

ORDレコード
ord-22f497ad4b6949c9a3a5cc1eba9f84bf
出典データセット
uspto-grants-1995_05
特許番号
US05420309

関連ノート

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