Water → 3-(1H-Indol-7-YL)propanenitrile

HRID 375683

反応式

HRID 375683 の反応式
[CH3:1][C:2]1[C:3]([N+:12]([O-])=O)=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=O.[CH3:15]OC(OC)N(C)C.[NH:23]1CCC[CH2:25][CH2:24]1.O>CN(C)C=O>[C:24]([CH2:25][CH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:4]2[C:3]=1[NH:12][CH:15]=[CH:5]2)#[N:23]

参加物

6

反応物 4

HCID 962WaterHCID 8082PiperidineHCID 78373Dimethylformamide dimethyl acetalHCID 79621Benzoic acid, 3-methyl-2-nitro-, methyl ester

生成物 1

HCID 199591053-(1H-Indol-7-YL)propanenitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of methyl 3-methyl-2-nitrobenzoate (43 g, 0.22 mole), dimethylformamide dimethyl acetal (52.5 g, 0.44 mole) and piperidine (18.7 g, 0.22 mole) in dimethylformamide (120 ml) is heated under reflux for 24 hours, cooled and poured into water to give the crude product.

後処理

  1. temperatureunder reflux for 24 hours
  2. temperaturecooled

出典と根拠

ORDレコード
ord-99b69e106a784f89aab343a351df0e89
出典データセット
uspto-grants-1996_01
特許番号
US05486612

関連ノート

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