Sodium Cyanide → 2-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile

HRID 375696

反応式

HRID 375696 の反応式
Br[CH2:2][C:3]1([CH2:7][OH:8])[CH2:6][O:5][CH2:4]1.[C-:9]#[N:10].[Na+]>C(O)C>[OH:8][CH2:7][C:3]1([CH2:2][C:9]#[N:10])[CH2:6][O:5][CH2:4]1

参加物

4

反応物 2

HCID 8929Sodium CyanideHCID 529264[3-(Bromomethyl)oxetan-3-yl]methanol

生成物 1

HCID 110079092-(3-(Hydroxymethyl)oxetan-3-yl)acetonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 42 g (0.23 mol) of [3-(bromomethyl)oxetan-3-yl] methanol (produced according to Example 1) in 420 ml of ethanol was refluxed with 13 g (0.265 mol) of sodium cyanide for 18 hours. After cooling to room temperature, the precipitated sodium bromide was filtered off and the filtrate concentrated by evaporation. The residue was distilled at 0.4 torr. The yield of product as a colorless oil was 16 g (54 percent). The boiling point of the product was 107° C./0.4 torr. Other data concerning the product was:

後処理

  1. filtrationthe precipitated sodium bromide was filtered off
  2. concentrationthe filtrate concentrated by evaporation
  3. distillationThe residue was distilled at 0.4 torr
  4. customwas 107° C.

出典と根拠

ORDレコード
ord-3fcf3ec291cc42e19566979fd5a4612d
出典データセット
uspto-grants-1996_01
特許番号
US05486622

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