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Piperidine → Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Ethanethiol, 2-(diethylamino)-, hydrochloride (1:1) | HCID 16031 | — |
| 反応物 | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| 反応物 | Benzyl 2-Benzylacrylate | HCID 10912012 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Phenylmethyl alpha-[[[2-(diethylamino)ethyl]thio]methyl]benzenepropanoate | HCID 19937709 | — |
反応手順
The oil prepared in Step 10 (1.5 g, 5.95 mmol) is dissolved under argon in methanol (22 mL). To this solution is added 2-diethylaminoethanethiol hydrochloride (1 g, 5.95 mmol), piperidine (0.78 mL, 7.85 mmol) and benzyltrimethylammonium hydroxide (0.25 mL, 0.6 mmol) , and the mixture is stirred at room temperature for 16 hours. The solvent is removed on a rotary evaporator and then the residue is purified by flash chromotography on silica gel to give the pure title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05488066 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-334a18af66234b7a8a23fa306b8c14f5 |
| 出典メモ | uspto-grants-1996_01 |