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Dimethylformamide → N-(1-cyclopentylpyrazol-5-yl) anthranilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Iodobenzoic acid | HCID 6941 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-cyclopentyl-1H-pyrazol-5-amine | HCID 1079792 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | N-(1-cyclopentylpyrazol-5-yl) anthranilic acid | HCID 54038843 | 68.5% |
反応手順
A mixture of 2-iodobenzoic acid (28 g, 0.113 mol), 5-amino-1-cyclopentylpyrazole (17 g, 0.113 mol), DMF (100 ml), potassium carbonate (16 g, 0.113 mol) and Cu(OAc) 2 (0.5 g) was refluxed overnight. The reaction mixture was poured into ice-water, and acidified with acetic acid to a pH of 5. The gum which formed was extracted with CH2Cl2 and the CH2Cl2 layer was washed with water, dried over MgSO4, and evaporated to afford 21 g of N-(1-cyclopentyl pyrazol-5-yl) anthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05488055 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-24c745ae42994c5db88ebabca4b6f325 |
| 出典メモ | uspto-grants-1996_01 |