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Dimethylformamide → N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 2-Chloro-4-nitrobenzoic acid | HCID 7448 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 触媒 | Cupric acetate monohydrate | HCID 165397 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid | HCID 21217705 | 63.3% |
反応手順
A mixture of 2-chloro-4-nitrobenzoic acid (4.03 g, 0.02 mol), 5-amino-1-ethylpyrazole (2.22 g, 0.02 mol), DMF (25 ml), K2CO3 (2.76 g, 0.02 mol) and Cu(OAc)2.H2O (0.5 g) was refluxed for 24 hours. The reaction mixture was cooled to room temperature, poured into ice-water and then acidified with acetic acid to a pH of 5. A solid formed which was collected by filtration and dried to afford 3.5 g (63%) of N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05488055 |
| 出典データセット | uspto-grants-1996_01 |
| ORD ID | ord-ba8f3ffd56584595a660795c7f7173aa |
| 出典メモ | uspto-grants-1996_01 |