関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Bromoterephthalic acid | HCID 68513 | — |
| 反応物 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(1-ethylpyrazol-5-yl)-4-carboxyanthranilic acid | HCID 21217714 | 45.4% |
反応手順
A mixture of 2-bromoterephthalic acid (4.8 g, 0.02 mol), DMF (50 ml), Cu(OAc)2 (0.2 g), 5-amino-1-ethylpyrazole (2.22 g, 0.02 mol) and K2CO3 (2.71 g, 0.02 mol) was heated at 135° C. overnight, then at reflux overnight. The reaction mixture was poured into water, acidified with acetic acid and the precipitate which formed was collected by filtration and dried to afford 2.5 g of N-(1-ethylpyrazol-5-yl)-4-carboxyanthranilic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05488055 |
|---|
| 出典データセット | uspto-grants-1996_01 |
|---|
| ORD ID | ord-9cc4debf8de34b8cb8ec94ed6aa9f752 |
|---|
| 出典メモ | uspto-grants-1996_01 |
|---|
