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Hydrochloric Acid → (4-Methoxyphenyl)glycolonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (4-Methoxyphenyl)glycolonitrile | HCID 36571 | — |
反応手順
To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05420349 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-d70c30dd3e6440eaa4466dd6b2a1c444 |
| 出典メモ | uspto-grants-1995_05 |