Dimethylamine → HCID 19361727、化合物

反応式

[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8](F)[N:7]=1.[CH3:13][NH:14][CH3:15].C(O)C>>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[N:7]=[C:8]([N:14]([CH3:15])[CH3:13])[CH:9]=[CH:10][CH:11]=1

参加物

反応物 3

HCID 674Dimethylamine

HCID 702Ethanol

HCID 105590502-(1,3-Dioxolan-2-yl)-6-fluoropyridine

生成物 1

HCID 19361727HCID 19361727、化合物

反応条件

温度: 100 °C

実験手順

0.60 g of 2-[1,3]dioxolan-2-yl-6-fluoropyridine (3.55 mmol) and 2.50 ml of dimethylamine at 33% in ethanol (17.7 mmol) are mixed and then the mixture is heated at the temperature of 100° C. for 12 hours. After evaporation under vacuum, the residue is taken up in chloroform, the mixture is washed with water, dried over magnesium sulfate, filtered and the chloroform is evaporated under vacuum. The title product is obtained in the form of a yellow oil which is used in the next stage without further purification.