Water → Methyl 6-formylpyridine-2-carboxylate

HRID 376298

反応式

HRID 376298 の反応式
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][OH:12])[N:6]=1)=[O:4].O>ClCCCl.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]=[O:12])[N:6]=1)=[O:4]

参加物

5

反応物 2

HCID 962WaterHCID 11513809Methyl 6-(hydroxymethyl)picolinate

生成物 1

HCID 12575850Methyl 6-formylpyridine-2-carboxylate収率 79%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 111,2-Dichloroethane溶媒

実験手順

A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered.

後処理

  1. customformed continuously
  2. customThe solid is removed by filtration on celite
  3. customthe dichloromethane is evaporated off

出典と根拠

ORDレコード
ord-7eeb93095125479cbb6978ebce1004e3
出典データセット
uspto-grants-2000_02
特許番号
US06020345

関連ノート

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