Mezacopride → N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide-N-oxide, hydrochloride

HRID 3763

反応式

HRID 3763 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH:9][C:10](=[O:22])[C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])[CH2:2]2.C([O-])(=O)/C=C/C([O-])=[O:27]>>[ClH:17].[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([NH+:9]([O-:27])[C:10](=[O:22])[C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=1[O:20][CH3:21])[CH2:2]2

参加物

3

反応物 2

HCID 3047745MezacoprideHCID 5460307Fumarate

生成物 1

HCID 131715440N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide-N-oxide, hydrochloride

実験手順

N-(1-Azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide, fumarate [1:1] is converted to the free base by partitioning with aqueous sodium hydroxide and methylene chloride. Using the procedure of Example 1, the free base is reacted with peracetic acid to obtain the N-oxide and finally with hydrogen chloride in isopropanol to give the hydrochloride.

後処理

  1. customby partitioning with aqueous sodium hydroxide and methylene chloride
  2. customthe free base is reacted with peracetic acid

出典と根拠

ORDレコード
ord-bc32b8c0b4ec4edd970f899e38ffb207
出典データセット
uspto-grants-1988_02
特許番号
US04722834

関連ノート

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