Methylamine → (5-Methyl-6-methylaminopyridin-2-yl)methanol
反応式
Cl[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[CH3:10].[CH3:11][NH2:12]>C(O)C>[CH3:10][C:3]1[CH:4]=[CH:5][C:6]([CH2:8][OH:9])=[N:7][C:2]=1[NH:12][CH3:11]参加物
4
実験手順
0.96 g of (6-chloro-5-methylpyridin-2-yl)-methanol (6.09 mmol) and 7 ml of methylamine at 33% in ethanol are heated at 120° C in a bomb for 96 hours. 2 ml of methylamine at 33% in ethanol are added every 24 hours. The reaction mixture is concentrated under vacuum and the title compound isolated by chromatography on a silica column (eluent: cyclohexane/ethyl acetate; 40:60).
後処理
- concentrationThe reaction mixture is concentrated under vacuum
出典と根拠
- ORDレコード
- ord-69fdbb6e9d2f48cb995681bbe4f123cd
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06020345
反応ノート
読み込み中…