Ammonia → (S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid

HRID 376404ノート

反応式

HRID 376404 の反応式
N.[CH:2]1[C:10]2[C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[O:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:15](=[O:28])[CH2:16][C@H:17]([NH:21]C(=O)C(F)(F)F)[C:18]([OH:20])=[O:19]>CO>[NH2:21][C@@H:17]([CH2:16][C:15]([C:3]1[CH:4]=[CH:5][C:6]2[O:7][C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[C:10]=2[CH:2]=1)=[O:28])[C:18]([OH:20])=[O:19]

参加物

4

反応物 2

HCID 222AmmoniaHCID 54131944(S)-4-dibenzofuran-2-yl-4-oxo-2-(2,2,2-trifluoroacetylamino)-butyric acid

生成物 1

HCID 53753679(S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid収率 100.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methanol (40 mL) was saturated with gaseous ammonia at room temperature. To this solution was added (S)-4-dibenzofuran-2-yl-4-oxo-2-(2,2,2-trifluoroacetylamino)-butyric acid (0.5 g, 0.0013 mol) obtained above in Example 1. The reaction mixture was stirred at room temperature for 24 hours and then concentrated to dryness in vacuo. The residue was recrystallized from boiling methanol to yield the title product as a white solid (0.37 g, quant); mp 182-187° C.

後処理

  1. customobtained above in Example 1
  2. concentrationconcentrated to dryness in vacuo
  3. customThe residue was recrystallized

出典と根拠

ORDレコード
ord-0c3a4a0b4ac04365a65f28eeecadabf7
出典データセット
uspto-grants-2000_02
特許番号
US06020366

反応ノート

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