Water → (S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

HRID 376405ノート

反応式

HRID 376405 の反応式
[NH2:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4].O.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C@@H:2]([CH2:6][C:7]([C:9]1[CH:21]=[CH:20][C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[CH:10]=1)=[O:8])[C:3]([OH:5])=[O:4])(=[O:25])[CH3:24]

参加物

4

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 53753679(S)-2-Amino-4-dibenzofuran-2-yl-4-oxo-butyric acid

生成物 1

HCID 53666229(S)-2-Acetylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid

実験手順

A suspension of (S)-2-amino-4-dibenzofuran-2-yl-4-oxo-butyric acid (0.025 g, 0.000082 mol) obtained above in Example 3 in acetic anhydride (2 mL) and water (4 mL) was sonicated (Cole Parmer 8850 Ultrasound Bath) for 15 minutes at room temperature. The resulting solution was then concentrated in vacuo, and the resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50, v/v) to yield the title product as a white solid; mp 166-170° C.

後処理

  1. concentrationThe resulting solution was then concentrated in vacuo
  2. customthe resulting residue was recrystallized from ethyl acetate/diethyl ether (50:50

出典と根拠

ORDレコード
ord-cc612f1cba554f73be4d2dd05f786133
出典データセット
uspto-grants-2000_02
特許番号
US06020366

反応ノート

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